|
|
[Print-friendly version]
| Associate Professor Yin Xiao |
| Research Theme: Medical Engineering |
|
Faculty of Built Environment & Engineering
|
School of Engineering Systems
|
|
Member of:
|
Institute of Health and Biomedical Innovation
|
| Position: |
Associate Professor |
| Email: |
yin.xiao@qut.edu.au |
| Phone: |
+61 7 3138 6240 |
| Fax: |
+61 7 3138 6030 |
| Location: |
QUT Kelvin Grove,
Q Block IHBI, Level 7,
Room 703F |
Profile
Qualifications, Career history and Professional and Group Associations
Qualifications
BDSc ( Hubei Med), MDSc ( Hubei Med), PhD (UQ)
Career History and biography
2005 - Current |
Associate Professor - Bone Tissue Engineering, Engineering Systems, BEE and IHBI, QUT |
| 2006 - 2009 |
Adjunct Professor - School of Dentistry, Wuhan University, Wuhan, China |
| 2005 - Current |
Adjunct Professor - School of Dentistry, Sun Yat-sen University, Guang Zhou, China |
| 2003 - 2007 |
Honorary Research Advisor - School of Dentistry, The University of Queensland, Brisbane, Australia |
| 2002 - 2005 |
Peter Doherty Fellowship - School of Life Science, Queensland University of Technology, Australia |
| 2000 - 2002 |
Research Officer - School of Dentistry, The University of Queensland, Australia |
| 1995 - 1997 |
Visiting Scientist - School of Dentistry, The University of Queensland, Australia |
| 1991 - 1995 |
Lecturer and Periodontist (Dentist) - School of Dentistry, Wuhan University, Wuhan, China |
Professional and Group Associations
Awards
2006 |
September - Lojia Scholar & Adjunct Professor, School of Dentistry, Wuhan University, Wuhan, China |
| 2005 |
May - Honour Professor, School of Dentistry, Zhong Shan University, Guang Zhou, China
Travel Award 10th Annual Scientific Meeting, Australian & New Zealand Orthopedic Research Society, Perth, Australia |
| 2004 |
NHMRC Travel Award, Bone Tissue Engineering Centre, Carnegie Mellon University, Pittsburgh, PA, USA
Poster-price in DOOC annual scientific meeting of the German Orthopaedic Association
Invited Visiting Senior Advisor, School of Dentistry, Sun Yat-Sen University, Guang Zhou, P.R. China
ASMR Premier Award Finalist. Australia Association of Medical Research Queensland 2004 Premier Award
05 Jan 04 to 19 Jan 04 - Award of OAP (Fellow - Inbound) Programme, Overseas A* Star Programme Singapore |
| 2003 |
04 Oct 03 to 05 Oct 03 - Invited Speaker, National Healthcare Group Annual Scientific Congress, Singapore
09 Oct 03 to 11 Oct 03 - Travel Award, 9th Annual Scientific Meeting, Australian & New Zealand Orthopedic Research Society, Adelaide, Australia |
| 2002 |
28 Jul 02 to 03 Aug 02 - Invited Keynote Speaker, The First Symposium of Tissue Engineering in Chinese Dentistry. Fujian Medical University, Fu Zhou, China
Peter Doherty Fellowship Award, National Health and Medical Research Council, Australia |
| 2001 |
Dean’s Commendation List for Outstanding PhD Thesis 2000, The University of Queensland, Australia |
| 1998 - 2000 |
Postgraduate Research Scholarship, The University of Queensland, Australia |
| 1997 |
Colgate Travel Award, Local IADR Meeting, Dunedin, New Zealand |
| 1994 |
Annual University Teaching Award, Hubei Medical University, China |
Research
Research areas and external collaborators
Research Areas
The treatment of many bone defects, especially large bone defects due to trauma, infections, tumours or genetic malformations, remains a major challenge in surgery. Although autologous bone graft is considered the most effective treatment, in practice this approach is limited by insufficient amount of donor tissue, coupled with donor site morbidity. On the other hand, immunological reactions in the recipient against allogeneic or xenogeneic bone grafts impose obvious limitations on their clinical applications. Recently, researchers have focused on the regeneration of bone using a bone tissue engineering approach. The main purpose of bone tissue engineering is to construct substitutes for bone grafts, in vitro and in vivo, in order to repair defects and restore normal function. My research focus is 1) understanding the cause of tissue damage; 2) developing strategies in cell delivery; 3) Manipulating stem cell differentiation and tissue forming potential.
Within the broad field of Medical Engineering, Associate Professor Yin Xiao and his research team has defined seven main research areas:
- Research Area 1: Cell and Molecular Biology
- Research Area 2: Bone and Cartilage Biology
- Research Area 3: Tissue Engineering
- Research Area 4: Stem Cell Biology
- Research Area 5: Cell and Biomaterial Interaction
- Research Area 6: Biomedical Engineering
- Research Area 7: Three-dimensional Tissue Culture
Teaching
Teaching areas and achievements and units taught
Teaching Areas
- Medical Engineering, Biomaterials and Bone Biology
Grants
Funding and selected list of awarded projects
Associate Professor Yin Xiao and his research team have been granted funds to conduct following research projects:
Development of gene-activated scaffolds as bone bioreactor for bone regeneration and osteointegration
2008 - 2010
Aust-China Exchange Fellowship for Doctor Yufeng Zhang
Total: $215,100 from NHMRC
Novel synthetic bio-mimic polymers for mesenchymal stem cell delivery
2008 - 2009
Total: $20,926 from The Prince Charles Hospital Foundation
Working with Professor Ross Crawford
Bilayered and growth factor-loaded composite scaffolds for the guided bi-differentiation of bone marrow stem cells
2008 - 2010
Total: $255,000 from ARC Discovery
Working with Professor Ross Crawford and Associate Professor Xigeng (Simon) Miao
Developing tissue engineered product for clinical application using a model of temporomandibular disorders
2008 - 2010
Total: $50,000 from Australia-China International Science Linkages
Department of Education, Science and Training, Australia
Integration of bone with cartilage via layered cell-scaffold constructs for the treatment of osteonecrosis
2007 - 2008
Total: $33,623 from Australia Orthopedic Association Foundation
Working with Professor Ross Crawford and Associate Professor Xigeng (Simon) Miao
Study of material-cell interactions for bone-cartilage regeneration with stem cells
2006 - 2007
Total: $75,000 from 2006 IHBI Seeding Grant
Working with Associate Professor Xigeng (Simon) Miao
Queensland University of Technology
Application of hyperbaric oxygen in bone tissue engineering--effect of hyperbaric oxygen treatment on bone marrow stem cells and 3-dimensional bone constructs
2006 - 2007
Total: $20,000 from Prince Charles Hospital Foundation
Working with Professor Ross Crawford and Doctor Jos Malda
Unique markers of differentiating human cells identified by subtractive immunization
Total: A$75,000 from 2005 IHBI Seeding Grant
Queensland University of Technology
Working with Doctor John Hooper, Associate Professor John Aaskov and Doctor Damein Harken
Separation of multipotent cells from osteophytes and its implication in tissue regeneration
2005 - 2007
Total: A$32,568 from Queensland Orthopedic Research Trust
Working with Professor Ross Crawford
An investigation of cell and extracellular matrix interactions and alterations in normal and osteoarthritic tissue: The subchondral bone plate
2005 - 2006
Total: A$23,615 from the Prince Charles Hospital Foundation
Working with Professor Ross Crawford and Doctor Mike Forswyth
Tissue-engineered bone regeneration from bone marrow-derived osteoblast progenitor cells
2004 - 2005
Total: $13,093 from NHMRC Traveling Award for Research Training
Development of Bone Substitute Materials for Clinical Applications
2003 - 2004
Total: A$300,000 from QUT Strategic Collaborative Program Grant
Working with Professor Mark Pearcy, Professor John Evans, Doctor Graeme Pettet, Associate Professor Clayton Adam, Doctor Edeline Wentrup-Byrne, Professor Adekunle (Kunle) Oloyede, Mr Cameron Lutton, Doctor Zee Upton, Professor Graeme George, Professor Ross Crawford, Professor Adrian Herington, Professor Sean McElwain, Doctor David Leavesley and Professor John Bell
Tissue engineering for human dental pulp tissue in vitro
2003
Total: A$5,750 from Australia Dental Research Fund Inc
Tissue-engineered bone regeneration from bone marrow-derived osteoblast progenitor cells
2002 - 2007
Total: A$266,000 from NHMRC
Tissue-engineered bone regeneration from osteoblasts and bone marrow stromal cells
2002 - 2003
Total: A$25,860 from The University of Queensland
A cell and polymer based composite scaffold for bone tissue regeneration
2002
Total: A$6,600 from Australia Dental Research Fund Inc
Working with Associate Professor William Young
Supervision
Selected list of student projects
Associate Professor Yin Xiao’s students have undertaken following funded research projects:
As Principal Supervisor:
Periosteum tissue Engineering and Its in vivo Application in Bone Defect Healing
Illustration of the structure of tissue engineered periosteum
Name: Wei Fan
Course: Ph. D.
Periosteum tissue engineering.
Identification and characterization of the molecular signatures of the mesenchymal stem cell
An unique cytoskeleton protein has been identified from subtractive immunization using stem cell clones, showing the cellular distribution.
Name: Navdeep Kaur
Course: Ph. D. in Medical Engineering
Identification of unique markers for mesenchymal stem cells.
Osteoblast and Chondrocyte Interactions in Osteoarthritis
Direct interaction of osteoblasts and chondrocytes derived from osteoarthritis patent can influence cell differentiation
Name: Indira Prasadam
Course: Ph. D.
Cartilage mineralization in the pathogenesis of osteoarthritis.
As Associate Supervisor:
Monitoring Stem Cell Cultures using Image Processing and Pattern Recognition Techniques
Changes of stem cell shape during extensive culture
Name: Christopher Bradhurst
Course: Master by Research in Medical Science
Computer recognition of stem cell morphology.
The elastic modulus of single osteoblast on MPP surface measure by AFM
Name: Chun Lai
Course: Ph. D.
Atomic force microscope (AFM) study of mesenchymal stem cells on biomaterials.
Single cell derived clonies of Bone Marrow Stromal Cells from Osteoarthritis patients: Molecular and cellular characterization
Clonal culture of bone marrow derived stem cells shows multi-lineage differentiation:
A) Osteogenic
B) Chondrogenic
C) Adipogenic
Name: Shobha Mareddy
Course: Ph. D.
Clonal study of bone marrow stem cells.
Separation and Characterization of Multipotent Cells from Osteophytes in Osteoarthritis
Osteophyte tissue contains cartilage, bone, bone marrow and fat tissues, providing evident of its origin from mesenchymal stem cells.
Name: Sanjleena Singh
Course: Ph. D.
Osteophyte derived mesenchymal stem cells.
The Role of Urothelium in Induced Ossification in Skeletal Muscle
Name: Christopher Podagiel
Course: Master by Research
Year Completed: 2007
Transitional epithelial induced bone formation.
Publications
Selected list of publications
Selected List of Publications
- Fan, Wei and Crawford, Ross W. and Xiao, Yin (2008) Structural and Cellular Differences between Metaphyseal and Diaphyseal Periosteum in Different-aged Rats. Bone 42(1):pp. 81-89.
- Xiao, Yin and Peng, Hui and Mao, Xueli and Whittaker, Andrew and Crawford, Ross W. (2008) Novel Synthetic Bio-Mimic Polymers for Cell Delivery. Advance Materials Research.
- Ivanovski, S. and Lichanska, M and Aniello, E and Xiao, Yin (2007) Gene Expression Profiling of Cells Involved in Periodontal Regeneration. Tissue Engineering 13(2):pp. 393-404.
- Mareddy, Shobha R. and Crawford, Ross W. and Brooke, Gary and Xiao, Yin (2007) Clonal Isolation and Characterization of Bone Marrow Stromal Cells from Osteoarthritis Patient. Tissue Engineering 13(4):pp. 819-829.
- Miao, Xigeng and Tan, Dawn Meifang and Li, Jian and Xiao, Yin and Crawford, Ross W. (2007) Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid). Acta Biomaterialia.
- Mishra, Sanjay K. and Collier, Lance R. and Chen, Gongfa and Steck, Roland and Schmutz, Beat and Wullschleger, Martin E. and Schuetz, Michael (2007) The effect of distraction vector orientation on the regenerate tissue during bilateral mandibular distraction . In Haynes, David and Zreiqat, Hala and Xu, Jiake and Fazzalari, Nick and Xiao, Yin, Eds. Proceedings Australian & New Zealand Orthopaedic Research Society- 13 Annual Scientific Meeting, pages pp. 48-48, Auckland, New Zealand.
- Singh, Sanjleena and Jones, Ben and Crawford, Ross W. and Xiao, Yin (2007) Characterisation of a mesenchymal-like stem cell population from osteophyte tissue. Stem Cells and Development.
- Wei, Xi and Ling, Junqi and Wu, Liping and Liu, Lu and Xiao, Yin (2007) Expression of mineralization markers in dental pulp cells. Journal of Endodontics 33(6):pp. 703-708.
- Wu, Dong and Malda, Jos and Crawford, Ross W. and Xiao, Yin (2007) Effects of hyperbaric oxygen on proliferation and differentiation of osteoblasts derived from human alveolar bone. Connective Tissue Research 48(4):pp. 206-213.
- Xiao, Yin and Fu, Huihua and Prasadam, Indira and Yang, Yaw-Ching and Hollinger, Jeffrey O. (2007) Gene Expression Profiling of Bone Marow Stromal Cells from Juvenile, Adult, Aged and Osteoporotic Rats: With an Emphasis on Osteoporosis. Bone 40(3):pp. 700-715.
- Xiao, Yin and Goss, Benjamin G. and Shi, Wei and Forsythe, Michael E. and Campbell, Alistair and Nicol, David L. and Williams, Richard P. and Crawford, Ross W. (2006) Laminin,VEGF, and bone matrix protein expression in uroepithelial bone induction-a canine model. Connective Tissue Research 47(2):pp. 102-109.
- Bartold, P. Mark and Xiao, Yin and Lyngstaadas, S. Petter and Paine, Michael L. and Snead, Malcolm L. (2006) Principles and applications of cell delivery systems for periodontal regeneration. Periodontol 2000 41(1):pp. 123-135.
- Rincon, Julio C. and Xiao, Yin and Young, William G. and Bartold, P. Mark (2005) Production of osteopontin by cultured porcine epithelial cell rests of malassez. Journal of Periodontal Research 40(5):pp. 417-426.
- Rincon, Julio and Xiao, Yin and Young, William G. and Bartold, P. Mark (2005) Enhanced proliferation, attachment and osteopontin expression of porcine periodontal cells with emdogain. Archives of Oral Biology 50(12):pp. 1047-1054.
- Schleicher, Iris and Parker, Anthony and Leavesley, David I. and Crawford, Ross W. and Upton, Zee and Xiao, Yin (2005) Surface modification by complexes of vitronectin and growth factors for human osteoblast culture. Tissue Engineering 11(11-12):pp. 1688-1698.
- Qian, H. and Xiao, Yin and Bartold, P. Mark (2004) Immunohistochemical localization and expression of fibromodulin in adult rat periodontium and inflamed human gingiva. Oral Disease 10(4):pp. 233-239.
- Xiao, Yin and Bartold, P. Mark (2004) Modulating effect of serum on the stimulation of plasminogen activator inhibitor 2 production in human gingival fibroblasts by lipopolysaccharide and interleukin-1b. Journal of the International Academy of Periodontology 6(3):pp. 81-88.
- Xiao, Yin and Young, William G. and Bartold, P. Mark and Hasse, Helen (2004) Development and transplantation of a mineralized matrix formed by osteoblasts in vitro for bone regeneration. Cell Transplantation 13(1):pp. 15-25.
- Xiao, Yin and Qian, H. and Young, William G. and Bartold, P. Mark (2003) Tissue engineering for bone regeneration using differentiated alveolar bone cells in collagen scaffolds. Tissue Engineering 9(6):pp. 1167-1177.
- Bartold, P. Mark and Xiao, Yin (2003) Use of a matrix scaffold for tissue engineering and bone regeneration, in Ellingsen, Jan Eirik and Lyngstadaas, S. Petter, Eds. Bio-implant interface : improving biomaterials and tissue reactions, chapter 14, pages pp. 243-254. CRC Press.
- Li, Huika and Bartold, P. Mark and Young, William G. and Xiao, Yin and Waters, Michael John (2001) Growth Hormone induces bone morphogenetic proteins and bone related proteins in the developing rat periodontium. Journal of Bone and Mineral Research 16:pp. 1068-1076.
- Yan, Fuhua and Marshall, Rod and Wynne, Susan and Xiao, Yin (2000) Glycosaminoglycans in Gingival Crevicular Fluid Of Patients with Periodontal Degree II Furcation Involvement Before and After Guided Tissue Regeneration: A Pilot Study. Journal of Periodontology 71:pp. 1-7.
 
|
